Studies on Synthetic Nucleosides. IV. A New Synthetic Method of Pyrimidine and Purine Ribosides
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چکیده
منابع مشابه
Effect of purine and pyrimidine ribosides on an isolated frog ventricle preparation.
Various purine and pyrimidine ribosides, with the exception of adenosine, have been found to exhibit a positive inotropic effect on an isolated strip of frog ventricle. Li a preparation responding maximally to one compound, the addition of a second compound led to a further increase in tension. This relationship was found to apply among the members of a given group (purine or pyrimidine) paired...
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Difluorocarbene, generated from trimethylsilyl fluorosulfonyldifluoroacetate (TFDA), reacts with the uridine and adenosine substrates preferentially at the enolizable amide moiety of the uracil ring and the 6-amino group of the purine ring. 2',3'-Di-O-acetyl-3'-deoxy-3'-methyleneuridine reacts with TFDA to produce 4-O-difluoromethyl product derived from an insertion of difluorocarbene into the ...
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Synthetic studies of C4-linked imidazole C-nucleosides toward biofunctional molecules are described, in which the following items are covered. 1) Stereoselective synthesis of imidazole C- and pyrazole C-nucleosides via diazafulvene intermediates. 2) Synthesis of tetrahydrofuranylimidazoles using a PhSe group efficiently and its application to the new human histamine H(3) receptor (hH(3)R) agoni...
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Pseudoisocytidine, a new synthetic pyrimidine C-nucleoside, which might be considered a more stable analog of 5-azacytidine, is active in vitro and in vivo, i.p. and p.o., against various 1-beta-D-arabinofuranosylcytosine-resistant lines of mouse leukemia. This antileukemic activity is blocked by cytidine but not by deoxycytidine or thymidine.
متن کاملPolymerase recognition of synthetic oligodeoxyribonucleotides incorporating degenerate pyrimidine and purine bases.
A universal base that is capable of substituting for any of the four natural bases in DNA would be of great utility in both mutagenesis and recombinant DNA experiments. This paper describes the properties of oligonucleotides incorporating two degenerate bases, the pyrimidine base 6H,8H-3,4-dihydropyrimido[4,5-c][1,2]oxazin-7-one and the purine base N6-methoxy-2,6-diaminopurine, designated P and...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1964
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.12.1471